"Weird" is subjective, whether they both do weird things or neither do weird things would be up to you to decide.
The Tsar Bomba worked by a fission bomb (like one of the early bombs dropped over Japan or the process that is used in nuclear power plants) initiating a fusion bomb (fusion is the same process that happens in the Sun), overall the energy released is to due a tiny fraction of the original mass being turned into energy, and both processes (especially fission) aren't very "efficient" compared to antimatter (most of the original mass/atoms just become different atoms). As in 100+ times less efficient if I remember correctly.
Antimatter would be the theoretically most efficient way to produce energy (whether in bombs or in power plants), because all the mass is turned into energy.